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| ADVAN11 |
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MEANING: Choice of Pharmacokinetic Model for PREDPP
CONTEXT: Option of NM-TRAN $SUBROUTINES record
USAGE:
$SUBROUTINES [ADVAN=]ADVAN11
SAMPLE:
$SUBROUTINE ADVAN11
DISCUSSION:
ADVAN11 is a routine in PREDPP's library which implements the kinetic
equations for the Three Compartment Linear Model.
Compt. Function Initial On/Off Dose Default Default
No. Status Allowed Allowed for Dose for Obs.
1 Central On No Yes Yes Yes
2 Peripheral 1 On No Yes No No
3 Peripheral 2 On No Yes No No
4 Output Off Yes No No No
TRANS routines that may be used: TRANS1, TRANS4, TRANS6
Basic PK parameters with TRANS1:
K (rate constant of elimination)
K12 (rate constant from central to peripheral 1)
K21 (rate constant from peripheral 1 to central)
K13 (rate constant from central to peripheral 2)
K31 (rate constant from peripheral 2 to central)
Basic PK parameters with TRANS4: (See TRANS4).
Basic PK parameters with TRANS6: (See TRANS6).
Additional PK parameters:
S1 - Scale for central compartment (also called SC)
S2 - Scale for peripheral compartment 1
S3 - Scale for peripheral compartment 2
S4 - Scale for output compartment (also called S0)
F1 - Bioavailability for central compartment
F2 - Bioavailability for peripheral compartment 1
F3 - Bioavailability for peripheral compartment 2
R1 - Rate for central compartment
R2 - Rate for peripheral compartment 1
R3 - Rate for peripheral compartment 2
D1 - Duration for central compartment
D2 - Duration for peripheral compartment 1
D3 - Duration for peripheral compartment 2
ALAG1 - Absorption lag for central compartment
ALAG2 - Absorption lag for peripheral compartment 1
ALAG3 - Absorption lag for peripheral compartment 2
F0 - Output fraction (also called F4, FO)
XSCALE - X parameter
Steady-state subroutines: SS11, SS6
Other required user or library routines:
Library: EXP3
Notes:
1 Analytical second derivatives used with the Laplacian method are
not obtained with ADVAN11. Numerical second derivatives must be
used.
2 Can be greatly speeded up if calls to PK can be limited. (Use
CALLFL=1 in $PK to call once per IR, and use the CALL data item
to force additional calls if and when necessary; e.g., when
covariates used in the PK model change.)
REFERENCES: None.
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