___________________________________________________________________
| |
| ADVAN12 |
|_________________________________________________________________|
MEANING: Choice of Pharmacokinetic Model for PREDPP
CONTEXT: Option of NM-TRAN $SUBROUTINES record
USAGE:
$SUBROUTINES [ADVAN=]ADVAN12
SAMPLE:
$SUBROUTINE ADVAN12
DISCUSSION:
ADVAN12 is a routine in PREDPP's library which implements the kinetic
equations for the Three Compartment Linear Model with First Order
Absorption.
Compt. Function Initial On/Off Dose Default Default
No. Status Allowed Allowed for Dose for Obs.
1 Depot Off Yes Yes Yes No
2 Central On No Yes No Yes
3 Peripheral 1 On No Yes No No
4 Peripheral 2 On No Yes No No
5 Output Off Yes No No No
TRANS routines that may be used: TRANS1, TRANS4, TRANS6
Basic PK parameters with TRANS1:
K (rate constant of elimination)
K23 (rate constant from central to peripheral 1)
K32 (rate constant from peripheral 1 to central)
K24 (rate constant from central to peripheral 2)
K42 (rate constant from peripheral 2 to central)
KA (rate constant of absorption)
Basic PK parameters with TRANS4: (See TRANS4).
Basic PK parameters with TRANS6: (See TRANS6).
Additional PK parameters:
S1 - Scale for depot compartment
S2 - Scale for central compartment (also called SC)
S3 - Scale for peripheral compartment 1
S4 - Scale for peripheral compartment 2
S5 - Scale for output compartment (also called S0)
F1 - Bioavailability for depot compartment
F2 - Bioavailability for central compartment
F3 - Bioavailability for peripheral compartment 1
F4 - Bioavailability for peripheral compartment 2
R1 - Rate for depot compartment
R2 - Rate for central compartment
R3 - Rate for peripheral compartment 1
R4 - Rate for peripheral compartment 2
D1 - Duration for depot compartment
D2 - Duration for central compartment
D3 - Duration for peripheral compartment 1
D4 - Duration for peripheral compartment 2
ALAG1 - Absorption lag for depot compartment
ALAG2 - Absorption lag for central compartment
ALAG3 - Absorption lag for peripheral compartment 1
ALAG4 - Absorption lag for peripheral compartment 2
F0 - Output fraction (also called F5, FO)
XSCALE - X parameter
Steady-state subroutines: SS12, SS6
Other required user or library routines:
Library: EXP3 EXP4
Notes:
1 Analytical second derivatives used with the Laplacian method are
not obtained with ADVAN12. Numerical second derivatives must be
used.
2 Can be greatly speeded up if calls to PK can be limited. (Use
CALLFL=1 in $PK to call once per IR, and use the CALL data item
to force additional calls if and when necessary; e.g., when
covariates used in the PK model change.)
REFERENCES: None.
Go to main index.
Created by nmhelp2html v. 1.0 written by Niclas Jonsson (Modified by AJB 5/2006,11/2007)