___________________________________________________________________
 |                                                                 |
 |                            ADVAN5 ADVAN7                        |
 |_________________________________________________________________|

 MEANING: Choice of Pharmacokinetic Model for PREDPP
 CONTEXT: Option of NM-TRAN $SUBROUTINES record

 USAGE:
 $SUBROUTINES [ADVAN=]ADVAN5

 SAMPLE:
 $SUBROUTINE ADVAN5

 DISCUSSION:
 ADVAN5 and ADVAN7 are routines in PREDPP's library which implement the
 general linear model.  The general linear model is used for systems in
 which a drug is distributed between compartments according  to  linear
 processes.   ADVAN7  may be used when the eigenvalues of the rate con-
 stant matrix are known to be real (which is true for  many  pharmacok-
 inetic  systems  such  as  mammillary models).  It is generally faster
 than ADVAN5.

 A $MODEL record is required to describe  the  compartments  and  their
 attributes.   The  $PK  record  (or,  if a user-supplied PK routine is
 used, the $MODEL record) describes how the compartments are linked.

 TRANS routines that may be used: TRANS1

 Suppose there are m compartments in the system, including  the  output
 compartment.

 Basic PK parameters with TRANS1:

   Kij (rate constant from compartment i to compartment j)
   Ki0 (alternate name for Kim)

   The letter T may be used as a separator between the two  compartment
   numbers,  e.g.,  KiTj.   The  letter  T is optional when there is no
   ambiguity, but required when there are two possible  interpretations
   of  the  numbers that follow K.  E.g., with 12 compartments, K111 is
   ambiguous.  It should be coded K1T11 or K11T1, depending if it  sym-
   bolizes  the  rate  constant from compartment 1 to compartment 11 or
   from compartment 11 to compartment 1.

 Additional PK parameters:

 For each compartment n in the system (n=1, ..., m):

   Sn - Scale for nth compartment
   S0 - Alternate name for scale for output compartment

 For each dosable compartment n in the system:

   Fn - Bioavailability for nth compartment
   Rn - Rate for nth compartment
   Dn - Duration for nth compartment
   ALAGn - Absorption lag for nth compartment

 Other additional PK parameters:

   F0 - Output fraction (also called Fm, FO)
   XSCALE - X parameter

 Required PREDPP Library subroutines:
 ADVAN5 - REXPON, RXSUBS
 ADVAN7 - RRXPON, RXSUBS

REFERENCES: Guide VI Section VII.C.5, VII.C.7
REFERENCES: Guide IV Section V.C.4


  
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