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| NONMEM ERROR MESSAGES |
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MEANING: Error messages
CONTEXT: NONMEM output
This feature is not fully documented. The interested user may be able L
to obtain more information by studying the appropriate sections of L
NONMEM code. L
USAGE: L
DISCUSSION: L
This is not a complete list. It includes only commonly seen error L
messages. L
Section I. Errors in the control stream L
FILE RECORD MISSING L
There is something wrong with the NONMEM control file. Probably L
it is an NM-TRAN control file (starting with $PROBLEM), rather L
than the FCON file produced by NM-TRAN. L
TOT. NO. OF OBSERVATIONS IN INDIVIDUAL REC NO. 1 (IN INDIVIDUAL REC L
ORDERING) EXCEEDS 50 L
SEE INSTALLATION GUIDE L
There are too many observation records in some individual record. L
To increase the limit beyond 50, NONMEM must be recompiled. see L
Guide III, Section 2.7. L
INITIAL ESTIMATE OF OMEGA HAS A NONZERO BLOCK WHICH IS NUMERICALLY NOT L
POSITIVE DEFINITE L
Possible cause: initial estimates of the variance and covariance L
terms in a block of OMEGA are not appropriate. Try other initial L
estimates. (Hint: it helps of the covariance estimates are small L
relative to the variance estimates.) L
USER CCONTR ROUTINE NOT USED, BUT THERE ARE NO EPSILONS, AND ETAS ARE L
TO BE ESTIMATED L
This can happen when POSTHOC etas are requested, but the data are L
single-subject data. The user may have included the POSTHOC L
option in error. L
UNABLE TO OBTAIN A SATISFACTORY INITIAL ESTIMATE OF VARIANCE- L
COVARIANCE COMPONENTS BLOCKS IN BLOCK SET 2 OF OMEGA ARE NUMERICALLY L
NOT POSITIVE DEFINITE L
This message is from the Initial Estimates Step. It identifies L
certain parameters whose initial estimates could not be obtained. L
Part II. Error in NONMEM tasks L
NUMBER OF CALLS TO SIMETA EXCEEDS NO. OF DATA RECORDS FOR INDIVIDUAL L
1 (IN INDIVIDUAL RECORD ORDERING) L
During the Simulation Step, an excessive number of calls to L
SIMETA have occurred. It may be that the users's PRED is L
attempting to obtain ETA from a truncated distribution but, due L
to some error, is rejecting all or virtually all values. (Possi- L
bly, the NEW option was omitted from the random source.) L
Some messages are preceded by lines such as the following that iden- L
tify the NONMEM routine that has detected the error: L
PROGRAM TERMINATED BY OBJ L
PROGRAM TERMINATED BY OBJ, ERROR IN CELS L
PROGRAM TERMINATED BY OBJ, ERROR IN ELS L
PROGRAM TERMINATED BY PRRES, ERROR IN ELS L
PROGRAM TERMINATED BY FNLETA L
OBJ computes the objective function; L
ELS computes Extended Least-Squares contribution to the objective L
function from the data from a single individual ("L1") record. L
CELS computes the conditional contribution to the ELS objective L
function; L
PRRES prints final results. L
FNLETA computes subject-specific (posthoc) eta values. L
WITH INDIVIDUAL 1 (IN INDIVIDUAL RECORD ORDERING) L
A line such as this identifies the record. L
Here are some commonly seen error messages. L
INTRAINDIVIDUAL VARIANCE OF DATA FROM OBS RECORD 1 ESTIMATED TO BE 0 L
VAR-COV OF DATA FROM INDIVIDUAL RECORD ESTIMATED TO BE SINGULAR L
A possible cause is the use of a proportional intra-individual L
error model while some predicted values for actual observa- L
tions are zero or close to zero. (For example, if the first dose L
is an infusion and there is a "base- line" observation at L
the start of the infusion, the predicted level will be zero.) L
MINIMIZATION TERMINATED DUE TO PROXIMITY OF NEXT ITERATION EST. TO A L
VALUE AT WHICH THE OBJ. FUNC. IS INFINITE L
NONMEM Theta-recovery has failed. L
OCCURS DURING SEARCH FOR ETA AT A NONZERO VALUE OF ETA L
An error occurred while NONMEM was obtaining conditional esti- L
mates of eta. L
REFERENCES: Guide I Section G
REFERENCES: Guide V Section 13
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