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 |                             NONMEM STEPS                        |
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 MEANING: Sequence of events in a NONMEM problem
 CONTEXT: NONMEM output

 DISCUSSION:

 NONMEM makes a single call to PRED (with ICALL=0), at the beginning of
 the run, to allow PRED to undertake run initialization.

 NONMEM makes a single call to PRED (with ICALL=1), at the beginning of
 every problem, to allow PRED to undertake problem initialization.

 SIMULATION STEP
      NONMEM  performs  simulation  (with  ICALL=4)   (if   $SIMULATION
      present).

 INITIAL ESTIMATE STEP
      NONMEM obtains initial estimates for theta, omega, sigma (if  the
      control stream does not provide all initial estimates).

 ESTIMATION STEP
      NONMEM searches for parameter values that minimize the  objective
      function (if $ESTIMATION present).

 NONPARAMETRIC STEP
      NONMEM obtains either marginal cumulatives or  conditional  (non-
      parametric) estimates of etas (if $NONPARAMETRIC present).

 COVARIANCE STEP
      NONMEM obtains a variance-covariance matrix of the estimator  and
      related  information  such  as  standard  errors  (if $COVARIANCE
      present).

 FINALIZATION STEP
      NONMEM obtains the following as needed:
           Posthoc estimates of eta.
           Classification into subpopulations (if a  MIXTURE  model  is
           used).
           PRED-defined values from NMPRD4  (for  tables  and  scatter-
           plots).

 NONMEM makes a single call to PRED (with ICALL=3), at the end of every
 problem (and subproblem), to allow PRED to undertake problem finaliza-
 tion.

 TABLE STEP
      NONMEM constructs tables (if $TABLE present).

 SCATTERPLOT STEP
      NONMEM constructs scatterplots (if $SCATTERPLOT present).

REFERENCES: Guide I Section A.4, G


  
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