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| PRCOMU |
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MEANING: PREDPP common
CONTEXT: For use with PREDPP
This feature is not fully documented. The interested user may be able L
to obtain more information by studying the appropriate sections of L
PREDPP code. L
USAGE: L
$PK L
"FIRST L
" COMMON /PRCOMU/ NEWBIO L
" LOGICAL NEWBIO L
" NEWBIO=.FALSE. L
DISCUSSION: L
The common allows the user to change the way bioavailability fraction L
parameters are used by PREDPP. Prior to 1990 (i.e., with NONMEM III / L
PREDPP I) bio-availability fractions applied to all transient doses L
except infusions (doses with AMT > 0 and RATE > 0 ). Similarly, it L
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did not apply to steady-state doses with multiple infusion and with a L
positive rate data item. L
After the change, bio-availability fractions apply to all transient L
(non steady-state) doses, and to steady-state doses for which the AMT L
is specified. The only doses to which bio-availability fractions do L
not apply are steady-state with constant infusion. L
By default, NEWBIO is true and the new rules apply. If NEWBIO is set L
to false, bioavailability fraction parameters revert to their pre-1990 L
behavior. L
REFERENCES: None.
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