___________________________________________________________________
 |                                                                 |
 |                                TRANS4                           |
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 MEANING: Choice of Translator Routine for PREDPP
 CONTEXT: Option of NM-TRAN $SUBROUTINES record

 USAGE:
 $SUBROUTINES [TRANS=]TRANS4

 SAMPLE:
 $SUBROUTINE ADVAN3 TRANS4

 DISCUSSION:
 TRANS4 is a routine in PREDPP's library which can be used with ADVAN3,
 ADVAN4,  ADVAN11, or ADVAN12.  It performs a reparameterization of the
 basic PK parameters to the internal parameters K, K12, K21, and KA.

 Basic PK parameters for ADVAN3, TRANS4:

   CL   clearance
   V1   central volume
   Q    intercompartmental clearance
   V2   peripheral volume

   Relationship:
   K=CL/V1
   K12=Q/V1
   K21=Q/V2

 Basic PK parameters for ADVAN4, TRANS4:

   CL   clearance
   V2   central volume
   Q    intercompartmental clearance
   V3   peripheral volume
   KA   absorption rate constant

   Relationship:
   K=CL/V2
   K23=Q/V2
   K32=Q/V3
   KA is unchanged

 Basic PK parameters for ADVAN11, TRANS4:

   CL   clearance
   V1   central volume
   Q2   intercompartmental clearance (central and periph. 1)
   V2   peripheral 1 volume
   Q3   intercompartmental clearance (central and periph. 2)
   V3   peripheral 2 volume

   Relationship:
   K=CL/V1
   K12=Q2/V1
   K21=Q2/V2
   K13=Q3/V1
   K31=Q3/V3

 Basic PK parameters for ADVAN12, TRANS4:

   CL   clearance
   V2   central volume
   Q3   intercompartmental clearance (central and periph 1)
   V3   peripheral 1 volume
   Q4   intercompartmental clearance (central and periph 2)
   V4   peripheral 2 volume
   KA   absorption rate constant

   Relationship:
   K=CL/V2
   K23=Q3/V2
   K32=Q3/V3
   K24=Q4/V2
   K42=Q4/V4
   KA=KA

REFERENCES: Guide VI Section VII.C.3, VII.C.4


  
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