___________________________________________________________________
 |                                                                 |
 |                                TRANS5                           |
 |_________________________________________________________________|

 MEANING: Choice of Translator Routine for PREDPP
 CONTEXT: Option of NM-TRAN $SUBROUTINES record

 USAGE:
 $SUBROUTINES [TRANS=]TRANS5

 SAMPLE:
 $SUBROUTINE ADVAN3 TRANS5

 DISCUSSION:
 TRANS5 is a routine in PREDPP's library which can be used with  ADVAN3
 or  ADVAN4.   It performs a reparameterization of the basic PK parame-
 ters to the internal parameters K, K12, K21, and KA.

 Basic PK parameters for ADVAN3, TRANS5:

   AOB     A/B
   ALPHA   alpha
   BETA    beta

   Relationship:
   K21=(AOB*BETA+ALPHA)/(AOB+1)
   K=(ALPHA*BETA)/K21
   K12=ALPHA+BETA-K21-K

 Basic PK parameters for ADVAN4, TRANS5:

   AOB     A/B
   ALPHA   alpha
   BETA    beta
   KA      absorption rate constant

   Relationship:
   K32=(AOB*BETA+ALPHA)/(AOB+1)
   K=(ALPHA*BETA)/K32
   K23=ALPHA+BETA-K32-K
   KA=KA

REFERENCES: Guide VI Section VII.C.3, VII.C.4


  
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