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| $MODEL |
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MEANING: Specifies the MODEL subroutine of PREDPP
CONTEXT: NM-TRAN Control Record
USAGE:
$MODEL [NCOMPARTMENTS=n1] [NEQUILIBRIUM=n2] [NPARAMETERS=n3]
[COMPARTMENT=([name] [attribute1] [attribute2] ...)] ...
[LINK compnamea [TO|AND] compnameb BY k [l]] ...
[I_SS=n] |
SAMPLE:
$MODEL NPARAMETERS=3
COMP=(DEPOT DEFDOSE INITIALOFF) COMP=(CENTRAL DEFOBS NOOFF)
DISCUSSION:
Required with a general ADVAN (ADVAN5-9).
OPTIONS:
NCOMPARTMENTS=n1
Total number of compartments other than the output compartment.
Default: the number of COMPARTMENT options. May also be coded
NCM or NCOMPS.
NEQUILIBRIUM=n2
Number of equilibrium compartments. Default: 0
NPARAMETERS=n3
Number of basic PK parameters. Default: The number of basic PK
parameters defined in the $PK abbreviated code. May also be
coded NPARAMS. May be 0 with the general non-linear models
(ADVAN6, ADVAN8, and ADVAN9).
COMPARTMENT= ([name] [attribute1] [attribute2] ...)
Each COMPARTMENT option defines a single compartment. Compart-
ments are numbered in the order in which they are defined. The
name option gives the name for the compartment. The name option
may not be one of the compartment attributes below, unless it is
enclosed in quotes (' or ").
If the name option is not used, then the compartment is named
"COMPn," where n is the compartment number.
Attributes are chosen from the following list. When an attribute
is not chosen, its opposite is the default.
INITIALOFF - Compartment is initially off.
NOOFF - Compartment may not be turned on or off.
NODOSE - Compartment may not receive a dose.
EQUILIBRIUM - Compartment is an equilibrium compartment (ADVAN9
only; implies NODOSE).
EXCLUDE - Compartment amount is excluded from the computation
of the amount (Amt) of the output compartment (ADVAN9 only).
[Amt=(total amount of drug thus far input into system) minus
(total amount remaining in the system)]
The following two attributes have no opposites.
DEFOBSERVATION - Compartment is the default observation com-
partment.
DEFDOSE - Compartment is the default dose compartment.
If no compartment has the DEFOBSERVATION attribute, the default
is the first compartment with the name CENTRAL; otherwise, the
first compartment. If no compartment has the DEFDOSE attri-
bute, the default is the first compartment with the name DEPOT
which may receive doses; otherwise, the first compartment which
may receive doses.
LINK compname [TO|AND] compname BY k [l]
Link clauses are used with ADVAN5 and ADVAN7, but only in the
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absence of $PK abbreviated code. They are rarely used, and are
described in Guide IV.
I_SS= n |
I_SS may be used with the general non-linear models (ADVAN6, |
ADVAN8, ADVAN9) to request the initial state feature of PREDPP. |
Values of n are |
0 No initial state state (the default) |
1 Initial steady state |
2 Initial steady state, adds to current compartment amounts. |
3 Initial steady state, use current compartment amounts as ini- |
tial estimates. |
(See advan68, advan9, prdpk4, $pk). |
RECORD ORDER:
Follows $SUBROUTINES
Precedes $PK (if present)
REFERENCES: Guide IV Section V.C.4
REFERENCES: Guide VI Section VI.B
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Created by nmhelp2html v. 1.0 written by Niclas Jonsson (Modified by AJB 5/2006,11/2007)