The NM-TRAN outputs obtained from using the NM-TRAN control stream listed in chapter I, along with the NM-TRAN data set listed in Appendix II, are given on the following pages of this appendix.
Data Set - FDATA
1 4.02 0. .74 79.6
1 0.25 2.84
1 0.57 6.57
1 1.12 10.5
1 2.02 9.66
1 3.82 8.58
1 5.1 8.36
1 7.03 7.47
1 9.05 6.89
1 12.12 5.94
1 24.37 3.28
2 4.4 0. 0. 72.4
2 .27 1.72
2 .52 7.91
2 1. 8.31
2 1.92 8.33
2 3.5 6.85
2 5.02 6.08
2 7.03 5.4
2 9. 4.55
2 12. 3.01
2 24.3 .90
3 4.53 0. 0. 70.5
3 .27 4.4
3 .58 6.9
3 1.02 8.2
3 2.02 7.8
3 3.62 7.5
3 5.08 6.2
3 7.07 5.3
3 9. 4.9
3 12.15 3.7
3 24.17 1.05
4 4.4 0. 0. 72.7
4 .35 1.89
4 .6 4.6
4 1.07 8.6
4 2.13 8.38
4 3.5 7.54
4 5.02 6.88
4 7.02 5.78
4 9.02 5.33
4 11.98 4.19
4 24.65 1.15
5 5.86 0. 0. 54.6
5 .3 2.02
5 .52 5.63
5 1. 11.4
5 2.02 9.33
5 3.5 8.74
5 5.02 7.56
5 7.02 7.09
5 9.1 5.9
5 12. 4.37
5 24.35 1.57
6 4. 0. 0. 80.
6 .27 1.29
6 .58 3.08
6 1.15 6.44
6 2.03 6.32
6 3.57 5.53
6 5. 4.94
6 7. 4.02
6 9.22 3.46
6 12.1 2.78
6 23.85 .92
7 4.95 0. .15 64.6
7 .25 .85
7 .5 2.35
7 1.02 5.02
7 2.02 6.58
7 3.48 7.09
7 5. 6.66
7 6.98 5.25
7 9. 4.39
7 12.05 3.53
7 24.22 1.15
8 4.53 0. 0. 70.5
8 .25 3.05
8 0.52 3.05
8 .98 7.31
8 2.02 7.56
8 3.53 6.59
8 5.05 5.88
8 7.15 4.73
8 9.07 4.57
8 12.1 3.
8 24.12 1.25
9 3.1 .0 .0 86.4
9 .3 7.37
9 .63 9.03
9 1.05 7.14
9 2.02 6.33
9 3.53 5.66
9 5.02 5.67
9 7.17 4.24
9 8.8 4.11
9 11.6 3.16
9 24.43 1.12
10 5.5 0. .24 58.2
10 .37 2.89
10 .77 5.22
10 1.02 6.41
10 2.05 7.83
10 3.55 10.21
10 5.05 9.18
10 7.08 8.02
10 9.38 7.14
10 12.1 5.68
10 23.7 2.42
11 4.92 0. 0. 65.
11 .25 4.86
11 .5 7.24
11 .98 8.
11 1.98 6.81
11 3.6 5.87
11 5.02 5.22
11 7.03 4.45
11 9.03 3.62
11 12.12 2.69
11 24.08 .86
12 5.3 0. 0. 60.5
12 .25 1.25
12 .5 3.96
12 1. 7.82
12 2. 9.72
12 3.52 9.75
12 5.07 8.57
12 7.07 6.59
12 9.03 6.11
12 12.05 4.57
12 24.15 1.17
Control Stream - FCON
FILE FSTREAM PROB THEOPHYLLINE POPULATION DATA DATA 1 0 132 5 0 ITEM 1 4 0 0 1 0 0 0 0 0 0 LABL ID DOSE TIME CP WT FORM (5E6.0) STRC 3 3 1 0 0 0 1 1 0 STRC 1 3 THCN 1 0 0 THTA 3 .08 .04 LOWR .1 .008 .004 UPPR 5 .5 .9 BLST 6 .005 .3 .0002 .006 .4 DIAG .4 ESTM 0 450 3 5 0 0 0 0 0 0 0 COVR 0 0 0 0 0 TABL 1 1 0 0 TABL 4 1 0 2 0 5 0 3 0 SCAT 1 2 SCAT 3 7 1 1 0 0 0 0 0 SCAT 3 8 1 1 0 0 0 0 0
File Stream - FSTREAM
DATA FDATA ****
Report - FREPORT
NM-TRAN VERSION II LEVEL 1.0 GENERATED DP SUBROUTINES: PRED NONMEM SUBROUTINES: ALL
Generated and User-Supplied Subroutines - FSUBS
SUBROUTINE PRED (ICALL,NEWIND,THETA,DATREC,INDXS,F,G,H)
IMPLICIT DOUBLE PRECISION (A-Z)
REAL DATREC
SAVE
INTEGER ICALL,NEWIND,INDXS
DIMENSION THETA(*),DATREC(*),INDXS(*),G(10,*),H(10,*)
DIMENSION ETA(10),EPS(10)
COMMON/ROCM12/MSEC
INTEGER MSEC
COMMON/NMPRD4/DS,W,KA,KE,CL,D,E,Y,A00019,A00023,A00027,A00096
COMMON/NMPRD4/A00101,A00102,A00100,A00095,A00099,A00098,A00097
COMMON/NMPRD4/A00103,C00011,BBBBBB(0979)
IF (ICALL.EQ.4) THEN
IF (NEWIND.NE.2) CALL SIMETA(ETA)
CALL SIMEPS(EPS)
ELSE
IF (NEWIND.NE.2) THEN
CALL GETETA(ETA)
EPS(01)=0.D0
ENDIF
ENDIF
DOSE=DATREC(02)
TIME=DATREC(03)
WT=DATREC(05)
IF(DOSE.NE.0.D0)THEN
DS=DOSE*WT
W=WT
ENDIF
KA=THETA(01)+ETA(01)
KE=THETA(02)+ETA(02)
CL=THETA(03)*W+ETA(03)
B00001=-KE*TIME
B00002=-KA*TIME
B00003=DEXP(B00001)
B00004=DEXP(B00002)
D=B00003-B00004
C A00014 = DERIVATIVE OF B00001 W.R.T. ETA(02)
A00014=-TIME
C A00015 = DERIVATIVE OF B00002 W.R.T. ETA(01)
A00015=-TIME
C A00016 = DERIVATIVE OF B00003 W.R.T. ETA(02)
A00016=B00003*A00014
C A00017 = DERIVATIVE OF B00004 W.R.T. ETA(01)
A00017=B00004*A00015
C A00019 = DERIVATIVE OF D W.R.T. ETA(01)
A00019=-A00017
B00005=KA-KE
E=CL*B00005
C A00025 = DERIVATIVE OF B00005 W.R.T. ETA(02)
A00025=-1.D0
C A00027 = DERIVATIVE OF E W.R.T. ETA(02)
A00027=CL*A00025
F=DS*KE*KA/E*D
B00006=DS*KA/E*D
B00007=DS*KE/E*D
B00008=-DS*KE*KA/E/E*D
C A00033 = DERIVATIVE OF F W.R.T. ETA(01)
A00033=B00008*CL+B00007
C A00034 = DERIVATIVE OF F W.R.T. ETA(02)
A00034=B00008*A00027+B00006
C A00035 = DERIVATIVE OF F W.R.T. ETA(03)
A00035=B00008*B00005
B00009=DS*KE*KA/E
C A00036 = DERIVATIVE OF F W.R.T. ETA(01)
A00036=B00009*A00019+A00033
C A00037 = DERIVATIVE OF F W.R.T. ETA(02)
A00037=B00009*A00016+A00034
Y=F+EPS(01)
C A00095 = DERIVATIVE OF Y W.R.T. ETA(02)
A00095=A00037
C A00096 = DERIVATIVE OF Y W.R.T. ETA(01)
A00096=A00036
C A00097 = DERIVATIVE OF Y W.R.T. ETA(03)
A00097=A00035
C C00011 = DERIVATIVE OF Y W.R.T. EPS(01)
C00011=1.D0
G(01,1)=A00096
G(02,1)=A00095
G(03,1)=A00097
IF (MSEC.EQ.1) THEN
C A00020 = DERIVATIVE OF A00016 W.R.T. ETA(02)
A00020=A00014*A00016
C A00021 = DERIVATIVE OF A00017 W.R.T. ETA(01)
A00021=A00015*A00017
C A00023 = DERIVATIVE OF A00019 W.R.T. ETA(01)
A00023=-A00021
B00010=DS/E*D
B00011=-DS*KA/E/E*D
C A00039 = DERIVATIVE OF B00006 W.R.T. ETA(01)
A00039=B00011*CL+B00010
C A00040 = DERIVATIVE OF B00006 W.R.T. ETA(02)
A00040=B00011*A00027
C A00041 = DERIVATIVE OF B00006 W.R.T. ETA(03)
A00041=B00011*B00005
B00012=DS*KA/E
C A00042 = DERIVATIVE OF B00006 W.R.T. ETA(01)
A00042=B00012*A00019+A00039
C A00043 = DERIVATIVE OF B00006 W.R.T. ETA(02)
A00043=B00012*A00016+A00040
C A00044 = DERIVATIVE OF A00031 W.R.T. ETA(02)
A00044=A00043
C A00045 = DERIVATIVE OF A00031 W.R.T. ETA(03)
A00045=A00041
B00013=DS/E*D
B00014=-DS*KE/E/E*D
C A00047 = DERIVATIVE OF B00007 W.R.T. ETA(01)
A00047=B00014*CL
C A00048 = DERIVATIVE OF B00007 W.R.T. ETA(02)
A00048=B00014*A00027+B00013
C A00049 = DERIVATIVE OF B00007 W.R.T. ETA(03)
A00049=B00014*B00005
B00015=DS*KE/E
C A00050 = DERIVATIVE OF B00007 W.R.T. ETA(01)
A00050=B00015*A00019+A00047
C A00051 = DERIVATIVE OF B00007 W.R.T. ETA(02)
A00051=B00015*A00016+A00048
C A00052 = DERIVATIVE OF A00032 W.R.T. ETA(02)
A00052=A00051
C A00053 = DERIVATIVE OF A00032 W.R.T. ETA(01)
A00053=A00050
C A00054 = DERIVATIVE OF A00032 W.R.T. ETA(03)
A00054=A00049
B00016=-DS*KA/E/E*D
B00017=-DS*KE/E/E*D
B00018=DS*KE*KA/E/E/E*D
C A00057 = DERIVATIVE OF B00008 W.R.T. ETA(01)
A00057=B00018*CL+B00017
C A00058 = DERIVATIVE OF B00008 W.R.T. ETA(02)
A00058=B00018*A00027+B00016
C A00059 = DERIVATIVE OF B00008 W.R.T. ETA(03)
A00059=B00018*B00005
B00019=DS*KE*KA/E/E/E*D
C A00060 = DERIVATIVE OF B00008 W.R.T. ETA(01)
A00060=B00019*CL+A00057
C A00061 = DERIVATIVE OF B00008 W.R.T. ETA(02)
A00061=B00019*A00027+A00058
C A00062 = DERIVATIVE OF B00008 W.R.T. ETA(03)
A00062=B00019*B00005+A00059
B00020=-DS*KE*KA/E/E
C A00063 = DERIVATIVE OF B00008 W.R.T. ETA(01)
A00063=B00020*A00019+A00060
C A00064 = DERIVATIVE OF B00008 W.R.T. ETA(02)
A00064=B00020*A00016+A00061
C A00065 = DERIVATIVE OF A00033 W.R.T. ETA(02)
A00065=CL*A00064
C A00066 = DERIVATIVE OF A00033 W.R.T. ETA(01)
A00066=CL*A00063
C A00067 = DERIVATIVE OF A00033 W.R.T. ETA(03)
A00067=CL*A00062
C A00068 = DERIVATIVE OF A00033 W.R.T. ETA(03)
A00068=B00008+A00067
C A00069 = DERIVATIVE OF A00033 W.R.T. ETA(03)
A00069=A00054+A00068
C A00070 = DERIVATIVE OF A00033 W.R.T. ETA(01)
A00070=A00053+A00066
C A00071 = DERIVATIVE OF A00033 W.R.T. ETA(02)
A00071=A00052+A00065
C A00072 = DERIVATIVE OF A00034 W.R.T. ETA(02)
A00072=A00027*A00064
C A00073 = DERIVATIVE OF A00034 W.R.T. ETA(03)
A00073=A00027*A00062
C A00074 = DERIVATIVE OF A00034 W.R.T. ETA(03)
A00074=B00008*A00025+A00073
C A00075 = DERIVATIVE OF A00034 W.R.T. ETA(03)
A00075=A00045+A00074
C A00076 = DERIVATIVE OF A00034 W.R.T. ETA(02)
A00076=A00044+A00072
C A00077 = DERIVATIVE OF A00035 W.R.T. ETA(03)
A00077=B00005*A00062
B00021=DS*KA/E
B00022=DS*KE/E
B00023=-DS*KE*KA/E/E
C A00080 = DERIVATIVE OF B00009 W.R.T. ETA(01)
A00080=B00023*CL+B00022
C A00081 = DERIVATIVE OF B00009 W.R.T. ETA(02)
A00081=B00023*A00027+B00021
C A00082 = DERIVATIVE OF B00009 W.R.T. ETA(03)
A00082=B00023*B00005
C A00083 = DERIVATIVE OF A00036 W.R.T. ETA(03)
A00083=A00019*A00082
C A00084 = DERIVATIVE OF A00036 W.R.T. ETA(02)
A00084=A00019*A00081
C A00085 = DERIVATIVE OF A00036 W.R.T. ETA(01)
A00085=A00019*A00080
C A00086 = DERIVATIVE OF A00036 W.R.T. ETA(01)
A00086=B00009*A00023+A00085
C A00087 = DERIVATIVE OF A00036 W.R.T. ETA(02)
A00087=A00071+A00084
C A00088 = DERIVATIVE OF A00036 W.R.T. ETA(01)
A00088=A00070+A00086
C A00089 = DERIVATIVE OF A00036 W.R.T. ETA(03)
A00089=A00069+A00083
C A00090 = DERIVATIVE OF A00037 W.R.T. ETA(03)
A00090=A00016*A00082
C A00091 = DERIVATIVE OF A00037 W.R.T. ETA(02)
A00091=A00016*A00081
C A00092 = DERIVATIVE OF A00037 W.R.T. ETA(02)
A00092=B00009*A00020+A00091
C A00093 = DERIVATIVE OF A00037 W.R.T. ETA(02)
A00093=A00076+A00092
C A00094 = DERIVATIVE OF A00037 W.R.T. ETA(03)
A00094=A00075+A00090
C A00098 = DERIVATIVE OF A00095 W.R.T. ETA(03)
A00098=A00094
C A00099 = DERIVATIVE OF A00095 W.R.T. ETA(02)
A00099=A00093
C A00100 = DERIVATIVE OF A00096 W.R.T. ETA(03)
A00100=A00089
C A00101 = DERIVATIVE OF A00096 W.R.T. ETA(01)
A00101=A00088
C A00102 = DERIVATIVE OF A00096 W.R.T. ETA(02)
A00102=A00087
C A00103 = DERIVATIVE OF A00097 W.R.T. ETA(03)
A00103=A00077
C A00101 = 2ND DERIV OF F W.R.T. ETA(01), ETA(01)
G(01,02)=A00101
C A00102 = 2ND DERIV OF F W.R.T. ETA(02), ETA(01)
G(02,02)=A00102
C A00099 = 2ND DERIV OF F W.R.T. ETA(02), ETA(02)
G(02,03)=A00099
C A00100 = 2ND DERIV OF F W.R.T. ETA(03), ETA(01)
G(03,02)=A00100
C A00098 = 2ND DERIV OF F W.R.T. ETA(03), ETA(02)
G(03,03)=A00098
C A00103 = 2ND DERIV OF F W.R.T. ETA(03), ETA(03)
G(03,04)=A00103
ENDIF
H(01,1)=C00011
F=Y
RETURN
END
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