NONMEM Users Guide Part VIII - Help Guide

INTRODUCTION

This guide is intended to provide experienced users of the NONMEM system with a fast way to locate information on a given reserved word or topic.

There are four sections:

Reserved Words
Miscellaneous Topics
Detailed Descriptions
Examples

The reserved words and miscellaneous topics appear in the left CRlumn of their respective sections, with titles of corresponding and relevant detailed descriptions and examples in the right column. The detailed descriptions provide brief summaries of the subject matter and are not intended to replace the other NONMEM guides, which should be consulted if more information is needed.

Text that reflects changes with NONMEM VI is marked with a bar in the margin. Entries that are entirely new with NONMEM VI are marked with bars only in the page heading and boxed text.

Descriptions of NM-TRAN control records have a special syntax that is described fully in Guide IV, section III.A. Please note that square brackets are used to surround an option or group of options, none of which need actually appear in the record. If they surround a group of options, a vertical line is used to separate these options in the description, and at most one of the options may be selected to actually appear in the record. If none are selected to appear, then the default option, listed first and indicated in boldface (if there is an option so indicated), is understood to apply.

Some of the examples are drawn from other NONMEM guides and sources, and some are new to this guide.

All sections are arranged in alphabetic order.

The help and html directories of the NONMEM VI distribution CD │ contain essentially the same content as this printed guide, │ enabling the contents of this guide to be searched and displayed │ on-line. │

HOW TO USE THIS GUIDE

Suppose one wishes to learn more about (say) nonlinear kinetics with PREDPP. The term "nonlinear" is listed among the miscellaneous topics in the second section:

One may then look at the detailed descriptions entitled "ADVAN6-ADVAN8", "ADVAN9", "ADVAN10" in the third section, or at the Michaelis Menten example in the fourth section.

Some of these titles also happen to be reserved words, and are therefore also listed in the first section.

Again, some of these titles ( DES, for example, is:

See also des, advan6 advan8, advan9.

REFERENCES: Guide IV, section V.C.7 (p. 75)
REFERENCES: Guide VI, section VI.C (p. 69)

Page numbers in the references are for the following editions:

Part I - Users Basic Guide - Nov. 1989
Part II - Users Supplemental Guide - Apr. 1988
Part III - Installation - Jan. 1998
Part IV - NM-TRAN Guide - Nov. 1992
Part V - NONMEM-PREDPP Introductory Guide - Nov. 1994
Part VI - PREDPP Guide - Nov. 1992
Part VII - Conditional Estimation Methods - Jan. 1998

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