___________________________________________________________________
 |                                                                 |
 |                         TIME SCALE PARAMETER                    |
 |_________________________________________________________________|

 MEANING: Time scale (TSCALE) parameter for PREDPP
 CONTEXT: Additional PK Parameters

 USAGE:
 $PK
  TSCALE= ....

 DISCUSSION:

 The time scale parameter is used with PREDPP.  It is an optional addi-
 tional  PK parameter.  With NM-TRAN, it is symbolized in the $PK block
 by either of the reserved variables TSCALE or XSCALE.

 If a time scale parameter is modeled by PK, then time  itself  may  be
 scaled  differently  between individuals. There is a single time scale
 parameter that multiplies all rate constants. The parameter acts  con-
 tinuously  (and  could  therefore  theoretically itself vary with time
 measured on an external clock).  It  can  only  be  used  with  linear
 kinetic  models. If it is not used, it can be ignored. If the value of
 the time scale parameter is not computed in PK, it  is  always  under-
 stood to be 1.

 The time scale parameter does not scale the duration parameter D of  a
 duration-modeled zero-order bolus dose.

 PREDPP ignores the time scale parameter with general non-linear models
 (ADVAN6, 8, 9).

 (See pk, $pk).

REFERENCES: Guide IV Section V.C.5
REFERENCES: Guide VI Section III.F.8


  
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