___________________________________________________________________
 |                                                                 |
 |                          TRANS (SUBROUTINE)                     |
 |_________________________________________________________________|

 MEANING: TRANS subroutine
 CONTEXT: User-supplied subroutine; for use with PREDPP

 USAGE:
 SUBROUTINE TRANS (ITRANS,IRGG,GG,NETAS)
 DIMENSION GG(IRGG,11,*)
 (If double precision is to be used):
 DOUBLE PRECISION GG
 (If single precision is to be used):
 REAL GG

 DISCUSSION:
 The TRANS subroutine translates (or transforms) the values for  a  set
 of basic PK parameters modeled in PK to a set of values for the inter-
 nal parameters required by the ADVAN.  The PREDPP Library has a number
 of  TRANS  subroutines,  representing different possible parameteriza-
 tions in PK, from which the user may choose. If a suitable  translator
 is not found in the Library, the user may write his own.

 Input/Output argument:

  ITRANS
      ITRANS=1: TRANS has been called for initialization at the  begin-
      ning of a NONMEM problem; one such call per problem.  ITRANS must
      be reset by TRANS to a number in the range  1-8999.  This  number
      appears on NONMEM output, allowing the user to identify the TRANS
      routine being used.

      ITRANS=2: On input the GG array has stored in it the values  com-
      puted  by  PK  (except  that were any PK parameter modeled in its
      logarithm form in PK, PREDPP would have already exponentiated its
      typical/subject-specific value and multiplied its eta derivatives
      by its exponentiated typical/subject-specific value).  On  output
      the  GG  array  should have stored in it the values that would be
      computed by PK were the internal parameters of the ADVAN  modeled
      directly in PK (and none in their logarithmic form).

      ITRANS=4: TRANS has been called during the Simulation Step.  Only
      the  first  column  of  the  GG  array  need  be computed as with
      ITRANS=2. Other columns need not be computed.

  GG  The array of PK parameters and their eta derivatives.
      The array is described elsewhere; (See pk).

 Input argument:

  NETAS
      The number of population etas in the problem.

 Certain variables are available in commons.  Their use is optional.

 Variables in read/write commons:

   IERPRD NETEXT ETEXT

 Variables in read-only commons:

   COMMON /PRCOM1/ NOETAS, SECOND
   LOGICAL NOETAS,SECOND

 When SECOND is true, PREDPP  requires  second-partial  derivatives  of
 etas.

REFERENCES: Guide VI Section III.M


  
Go to main index.
  

    Created by nmhelp2html v. 1.0 written by Niclas Jonsson (Modified by AJB 5/2006,11/2007)