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| ADVAN (GENERAL) |
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MEANING: Choice of Pharmacokinetic Model for PREDPP
CONTEXT: Option of NM-TRAN $SUBROUTINES record
USAGE:
$SUBROUTINES [ADVAN=]ADVANn
SAMPLE:
$SUBROUTINE ADVAN1
DISCUSSION:
PREDPP contains a library of routines, called ADVAN routines, which
implement specific kinetic models. Exactly one ADVAN routine must be
selected for each NONMEM/PREDPP run. Its function is to "advance" the
kinetic system from one state time point to the next. The ADVAN rou-
tines are:
ADVAN1 One Compartment Linear Model
ADVAN2 One Compartment Linear Model with First Order Absorption
ADVAN3 Two Compartment Linear Model
ADVAN4 Two Compartment Linear Model with First Order Absorption
ADVAN5 General Linear Model
ADVAN6 General Nonlinear Model
ADVAN7 General Linear Model with Real Eigenvalues
ADVAN8 General Nonlinear Model with Stiff Differential Equations
ADVAN9 General Nonlinear Model with Equilibrium Compartments
ADVAN10 One Compartment Model with Michaelis-Menten Elimination
ADVAN11 Three Compartment Linear Model
ADVAN12 Three Compartment Linear Model with First Order Absorption
With a general ADVAN (numbered 5 through 9), a $MODEL record (or
user-supplied MODEL subroutine) must be provided to specify certain
details of the model. With ADVAN 6, 8, and 9, a $DES block (or DES
subroutine) must be provided to evaluate the differential equations.
With ADVAN9, $AES and $AESINITIAL blocks (or AES subroutine) must also
be provided to evaluate the algebraic expressions. With ADVAN6, 8, 9,
10, and/or SS6, TOL must be specified by means of the TOL option of
the $SUBROUTINES record (or a $TOL block or TOL subroutine).
To use a given ADVAN routine, follow two steps:
1. Specify this ADVAN to NM-TRAN on the $SUBROUTINES record. This
enables NM-TRAN to interpret other records such as $PK.
2. Include the specified ADVAN routine when building the NONMEM exe-
cutable. NM-TRAN itself places the name of the specified ADVAN
routine (and any other routines from the PREDPP library required
by that ADVAN) in its output file FREPORT.
The NMFE6 command automatically includes the correct ADVAN routine in L
the NONMEM executable. L
REFERENCES: Guide VI Section I, III.A, VII.C
REFERENCES: Guide IV Section V.C.3, V.C.5
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