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 |                      OUTPUT FRACTION PARAMETER                  |
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 MEANING: Output fraction (F0) parameter for PREDPP
 CONTEXT: Additional PK Parameters

 USAGE:
 $PK
  F0= ....

 DISCUSSION:

 The output fraction parameter is used with PREDPP.  It is an  optional
 additional  PK  parameter.  With NM-TRAN, it are symbolized in the $PK
 block by any one of the reserved variables FO, F0, or Fn, where  n  is
 the compartment number of the output compartment.

 With any of the kinetic models a (peripheral)  output  compartment  is
 always  present.  Associated  with this compartment is a PK parameter,
 the output fraction , denoted here by Fo. Of the entire amount, Ao, of
 drug  introduced  into  the system by various dosage patterns and then
 eliminated from the system during a given time interval, a fraction Fo
 of
  Ao goes into this output compartment.

 If the output compartment is never turned on, the output fraction  can
 be ignored. If the value of the output fraction is not computed in PK,
 it is always understood to be 1

 The use of Fo depends on the assumption that the  rate  of  change  of
 drug  amount in the output compartment is linear in the other compart-
 ment amounts. Other than this linearity restriction, the system can be
 nonlinear.

 (See cmt, pk, $pk, default_compartment).

REFERENCES: Guide IV Section V.C.5
REFERENCES: Guide V Section 7.4.5
REFERENCES: Guide VI Section III.F.7


  
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